![]() ![]() The elderly patients are more vulnerable to the hypotension associated postoperative adverse outcomes due to age-related changes in cardiovascular physiology 3. Patients are most likely to suffer from hypotension during induction of general anesthesia due to the depression of cardiac function and vasodilation caused by anesthetic drugs, as well as lack of surgical stimulation, particularly in the elderly patients 8, 9. Severe episodes of intraoperative hypotension have been reported to be related to the occurrence of various postoperative adverse events 3, 4, 5, 6, 7. Hypotension is a common complication in patients under general anesthesia 1, which may lead to organ hypoperfusion and ischemia 2. Intravenous granisetron reduced the requirement of prophylactic ephedrine in preventing hypotension after general anaesthesia induction in elderly patients. The conclusion was further supported by probit regression analysis (0.09 mg kg −1 in group granisetron and 0.14 mg kg −1 in group control). In the up-down sequential allocation analysis, the ED50 of ephedrine was significantly lower in group granisetron (0.08 mg kg −1 ) when compared with group control (0.14 mg kg −1 ) (P < 0.001). The up-down sequential allocation analysis and probit regression was used to calculate the effective dose for 50% of patients (ED50) with prophylactic ephedrine. The prophylactic dose for each patient was increased or decreased by 0.05 mg/kg based on the efficacy results of the previous patient. ![]() The first patient in each group received a prophylactic dose of ephedrine (0.15 mg kg −1) to prevent hypotension. ![]() Sixty elderly patients were randomly assigned to receive granisetron or saline control 30 min before induction of general anaesthesia. In the current study, we aimed to investigate the effect of intravenous granisetron on prophylactic ephedrine for preventing hypotension after general anaesthesia induction in elderly patients. However, it remains unknown whether they could also prevent hypotension after induction of general anaesthesia. Serotonin 3 receptor antagonists, a commonly used drug for preventing postoperative nausea and vomiting, have recently been reported to decrease the incidence of hypotension and the need for vasoactive drugs after spinal anaesthesia in obstetric surgery. ![]()
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